Labrune syndrome: A unique leukoencephalopathy

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Leukoencephalopathy with cerebral calcifications and cyst: Labrune syndrome.

1 Professor da Faculdade de Medicina da Universidade de Fortaleza, UNIFOR, Fortaleza CE; Médico Neurologista Infantil do Hospital Estadual Albert Sabin, SESA-CE; Médico Colaborador do grupo de neurogenética do Centro de Estudos do Genoma Humano, ICB-USP, São Paulo SP, Brazil; 2 Acadêmico de Medicina da UNIFOR, Fortaleza CE, Brazil; 3 Neurologista do Hospital Geral de FortalezaHGF-SESA-CE, Forta...

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Teaching NeuroImages: Adult-onset leukoencephalopathy with intracranial calcifications and cysts (Labrune syndrome).

A 42-year-old woman was admitted for a complex partial seizure. At age 18 years, she had transient diplopia, which was considered a simple strabismus. Current examination revealed a left VI cranial nerve palsy and right arm hyperreflexia. Neuroimaging showed multiple intraparenchymal cystic lesions in white matter (figure), multiple calcifications in basal ganglia, and extensive bilateral leuko...

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Longitudinal clinical and neuro-radiological findings in a patient with leukoencephalopathy with brain calcifications and cysts (Labrune syndrome)☆

Since she was 4 years old, the patient had exhibited frequent convulsive seizures, and she experienced severe headaches and depression in adulthood. At the age of 37 years, cerebral calcifications were detected, but she exhibited no cognitive or motor problems. She suffered a cerebral haemorrhage at 49 years old and experienced cognitive dysfunction, dysarthria, dysphagia, and left-hemiparesis ...

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ژورنال

عنوان ژورنال: Annals of Indian Academy of Neurology

سال: 2017

ISSN: 0972-2327

DOI: 10.4103/0972-2327.192386